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"This monograph provides both an introduction to and a thorough exposition of the theory of rate-independent systems, which the authors have been working on with a lot of collaborators over 15 years. The focus is mostly on fully rate-independent systems, first on an abstract level either with or even without a linear structure, discussing various concepts of solutions with full mathematical rigor. Then, usefulness of the abstract concepts is demonstrated on the level of various applications primarily in continuum mechanics of solids, including suitable approximation strategies with guaranteed numerical stability and convergence. Particular applications concern inelastic processes such as plasticity, damage, phase transformations, or adhesive-type contacts both at small strains and at finite strains. A few other physical systems, e.g. magnetic or ferroelectric materials, and couplings to rate-dependent thermodynamic models are considered as well. Selected applications are accompanied by numerical simulations illustrating both the models and the efficiency of computational algorithms. In this book, the mathematical framework for a rigorous mathematical treatment of ""rate-independent systems"" is presented in a comprehensive form for the first time. Researchers and graduate students in applied mathematics, engineering, and computational physics will find this timely and well written book useful."

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One aim of this book is to examine the causes of fluctuations in the mark/dollar, pound/dollar, and yen/dollar real exchange rates for the period 1972-1994 with quarterly data to determine appropriate policy recommendations to reduce these movements. A second aim is to investigate whether the three real exchange rates are covariance-stationary or not and to which extent they are covariance-stationary, respectively. These aims are reached by using a two-country overshooting model for real exchange rates with real government expenditure and by applying Johansen's maximum likelihood cointegration procedure and a factor model of Gonzalo and Granger to this model.

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

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