Peyronie's disease involves scar tissue formation causing penile curvature and discomfort. This condition is common in middle-aged men and can be managed with medications, therapies, or surgery. Early diagnosis and treatment are crucial for optimal results and preserving sexual health.

Peyronie's disease is a male condition characterized by fibrous scar tissue buildup inside the penile shaft. This plaque formation often occurs after trauma or internal bleeding within penile tissues. Contributing factors include nutrient deficiencies, hormonal imbalances, certain medications, and genetic tendencies.

The condition commonly results in penile curvature, causing pain and emotional distress during intimacy. It primarily affects men in middle age, with an estimated prevalence of 1% to 8%.

Key Signs and Symptoms

Pain during erection or intercourse

Penile bending or curvature

Weak or soft erections

Reduced penile length

Difficulty with sexual activity

Psychological impact

Preventive Tips

Stop smoking

Maintain regular physical activity

Limit alcohol intake

Avoid unprescribed drugs

Treatment Approaches

Management depends on severity. Mild cases may resolve spontaneously, while persistent symptoms might require medical intervention.

Injectable Therapies

Collagenase (Xiaflex): FDA-approved for moderate to severe curvature, breaking down collagen to reduce plaque and bend. Effectiveness continues to be studied.

Verapamil: Intralesional injection aimed at decreasing collagen production and alleviating pain.

Interferon: Promotes scar tissue dissolution, improving curvature and discomfort.

Shockwave Therapy

High-frequency sound waves are used to stimulate tissue healing in calcified plaques. Usually performed over three to five sessions.

Surgical Options

Reserved for severe or unresponsive cases, surgeries can involve scar removal, tissue grafting, penile lengthening, or prosthetic implantation to straighten and restore function.

Early-Stage Medications

Vitamin E

Tamoxifen

Colchicine

Carnitine

Potassium aminobenzoate

Sildenafil

Tadalafil

Pentoxifylline

Prompt consultation with a healthcare provider is vital for diagnosis and tailored treatment to manage symptoms effectively.